I'm extremely upset about her illness.

她的病令我非常不安。

youdao

A few days ago, I was extremely upset.

几天前，我十分烦心。

youdao

"Why, dear, I would be extremely upset, " said the husband. "Why do you ask such a question?

“我会非常的伤心，亲爱的，”丈夫回答道，“但是为什么你要问这个？”

youdao

The difference between the extremely happy people and extremely unhappy people is not that one gets sad, of upset, or anxious, or depressed; and the other does not.

极其快乐的人和极其不快乐的人,区别不是在于一个会伤心，难过，焦虑或抑郁;,而另一个不会。

哈佛公开课 - 幸福课课程节选

He seemed extremely upset and didn't appear to want to talk, she said.

CNN: Boy killed in Boston blast wrote, 'No more hurting people'

One of Wendleton's clients, a financial services executive, phoned her last week extremely upset because she'd been let go.

FORBES: Magazine Article

Staff at a pet shop in Liverpool have been left "extremely upset" after a large lizard was stolen during a burglary, police have said.

BBC: Black-throated monitor lizard