Diabetic Nephropathy is one of the serious complications of diabetes. The basic pathologic change is the accummulation of the extracellular material of glomcrulus (ECM).
糖尿病肾病是糖尿病严重并发症之一,其基本病变是肾小球细胞外基质(ECM)积聚。
参考来源 - 旱莲草调节糖尿病肾病基质金属蛋白酶系统失衡的机理研究The orientation of embryonic stem cell is in addition to cellular differentiation of various definitive transcription factors, extracellular material inhibition mediated by endogenous factors is also essential.
胚胎干细胞的这种定向分化能力除了细胞内各种转录因子的内在决定因素外,细胞间因子的分化诱导、抑制作用及细胞外物质的介导作用等外源性因素也是必不可少的。
参考来源 - 小鼠胚胎干细胞诱导分化为肾脏样细胞的实验研究·2,447,543篇论文数据，部分数据来源于NoteExpress
To obtain single cells for tissue engineering, researchers have to first break tissue apart, using enzymes that digest the extracellular material that normally holds cells together.
为了得到用于组织工程的单个细胞，研究者们首先必须将组织分离打散，即用酶消化原本组织中连接细胞的细胞外基质。
This enables the cell to capture material from the extracellular environment and to respond to cues detected by externally oriented receptors.
这就使细胞能从细胞外的环境中捕获原料，并且回应那些能被外部指向型受体接收的信息。
Conclusion the lamina cribrosa contains a specialized extracellular matrix of the central nerve system made up of plates of material resembling basement membrane.
结论筛板是中枢神经系统的一种特殊组织，由类似基底膜样物质组成，赋予筛板弹性和基底膜的机械稳定性。
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