由于第3、第4代头孢类药物在猪当中的应用，我们已经发现产生广谱贝塔内酰胺酶（ESBL）的细菌开始增多，例如沙门氏菌某些种、大肠杆菌，尤其在美国，欧盟的问题范围小得多，但意外的是，这里发生率最高的是肉鸡部门。
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ESBL-producing bacteria ESBLs菌株
Objective: To explore the means of preventing and treating on the neonatal infections by ESBL of E. coli.
目的：探讨预防和治疗新生儿大肠杆菌esbl感染的手段。
Conclusions SHV-12 ESBL has a highest affinity to ceftazidime and cefotaxime expresses a maximal catalytic efficacy to cephalothin.
结论SHV - 12型esbl对头孢他啶和头孢噻肟具有高的亲和力，而对头孢噻吩有最大的催化效能。
Between the positive strains for ESBL and the negative strains , there were some significant antimicrobial resistance differences(P<0.05);
ESBL阳性与ESBL阴性大肠埃希菌相比较其对，喹诺酮类、氨基糖甙类、磺胺类的耐药性差异存在显著性（P<0.05）；
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