Some people even have a genetic defect in the enzymes in their liver that break down nicotine, whereby the mutant enzyme is much less effective at metabolizing nicotine than the normal variant.

有些人的肝脏中分解尼古丁的酶有遗传上的缺陷，因此这种突变的酶在代谢尼古丁时的作用就比正常的变异体的作用小。

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"With enzyme replacement, it's a single defect, and you correct that error, " says Joon Yun , partner at money management firm Palo Alto Investors, which has owned BioMarin stock for several years.

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