These results showed that the ionizing group of the enzyme active center is the carboxyl group.

化学修饰法研究进一步证明侧链羧基是酶的必需基团，并测定出酶活性必需的羧基数为一个。

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Objective To study the effects of phosphate on guanidine denaturation of human placental alkaline phosphatase (HPAP) and provide a theoretical basis for flexibility hypothesis of enzyme active sites.

目的观察磷酸盐对人胎盘碱性磷酸酶(HPAP)胍变性的影响，为酶活性部位的柔性理论提供证据。

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C-Sixty's fullerene-based drug scuppers this process by settling snugly into the enzyme's active site, stopping it functioning.

ECONOMIST: Nanotechnology in biology

Using this data, Adams in 1995 concocted an unusual boron molecule that snuggled into one of the enzyme's active sites and blocked its function.

FORBES: Magazine Article

These work by binding chemically to that enzyme's active site to inhibit its action. (Protease cuts the raw chain of virus protein produced by a subverted cell into functional molecules.) However, the mechanism is not quite identical.

ECONOMIST: Nanotechnology in biology