Methods Serum samples from 188 chronic hepatitis B patients with lamivudine therapy were collected and quantitatively tested with real-time PCR for HBV DNA and YMDD mutations.

方法将接受拉米夫定治疗的188例患者根据治疗时间进行分组，采用实时荧光PCR方法定量检测各组患者血清HBV DNA水平和酪氨酸-甲硫氨酸-天冬氨酸-天冬氨酸（YMDD）变异。

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To guide reasonably antival therapy in clinic and make therapic remedy, it is necessary for HBV-infected patients before or after antiviral therapy to detect HBV YMDD mutations.

HBV感染患者在治疗前后有必要检测是否存在HBV YMDD 变异株感染，为指导临床科学合理用药和制定治疗方案提供依据。

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Conclusion it would be helpful to adjust the therapeutic regimen by testing YMDD mutations in patients who receive lamivudine therapy more than 6 months without complete virologic response.

结论对拉米夫定治疗6个月以上而没有达到病毒学完全应答的患者进行YMDD变异检测，有助于及时调整治疗方案。

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