Upstream open reading frame
Upstream open reading frame
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abstract:
An Upstream Open Reading Frame (uORF) is a very short Open Reading Frame (ORF) within the 5'untranslated region of a mRNA that is a common mechanism for the regulation of eukaryotic genes expression. Expression of the uORF typically interferes with the expression of a downstream primary ORF, which corresponds to the gene under regulation.
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