Knudson用二次突变假说（two-hit hypothesis）来解释视网膜母细胞瘤的遗传性与散发性，也可解释遗传性视网膜母细胞瘤的显性遗传与肿瘤抑制基因（隐性基因）的关系。
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While the two-hit hypothesis is useful conceptually, making predictions for particular individuals is still a challenge.
虽然这“两步假设法”理论上行得通，可是要预测特定个体，依然是一个挑战。
Background and objective: the hypothesis of "two hit" model suggests that at least two classes of gene mutations are responsible for the leukemogenesis.
背景与目的：“两次打击”学说认为，白血病的发生常常累及两大类以上基因的突变。
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