Scruton's sending-off proved a key turning point and Saints immediately made the extra man count with Wellens and Talau getting Meli over for his second try to make it 18-6.
It got worse for Wigan on 31 minutes when Richard Horne somehow managed to get over for his 100th career try, despite the efforts of four Wigan defenders who failed to stop him getting the ball over the line.
"Having him behind the plate, that comfort level, getting to spring training I don't have to try to go over my game plan with three or four different catchers, " Marcum said.