There are three major problems with this approach.

这种做法存在三大问题。

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The problem of communications should be speedily settled, but even more so, the three major problems should be speedily settled.

交通问题应该迅速解决，这三大问题尤其应该迅速解决。

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The problem of the marine environment is one of the three major problems that we human beings are faced with in the twenty-first century.

海洋环境问题是二十一世纪我们人类所面临的人口、资源、环境三大问题之一。

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But rather than celebrating Nigeria's status as not only host nation but also defending champion of this event, local organizers and FIFA officials alike will instead be holding their collective breath, hoping that the country pulls through the three-week long tournament without any major problems.

VOA: standard.2009.10.22

But there are three major problems which have been true of all of the various attempts from PDAs onwards to produce just such a one stop machine.

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E-Verify has three major problems.

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The problems at Radlett in Hertfordshire led to major changes to services run by three train companies - Southeastern, East Midlands Trains and First Capital Connect (FCC).

BBC: Radlett cable failure causes major rail delays