abstract:A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur.
The pre-replicationcomplex (Pre-RC) formsinlate mitosis/early G1 phase beginning with the binding ofCDT1andcdc6 to the origin, whichallows binding of the heterohexameric MCM2-7 complex.