The phenotypic transformation of fibroblasts to myofibroblasts exist in Animal model of pulmonary fibrosis,nuclear factor-kappa B activation can promote fibroblast phenotype transdifferentiation and play an important role in pulmonary fibrosis.
2、成纤维细胞向肌成纤维细胞表型转化可能在肺间质纤维化病理过程中具有重要作用,NF-κB活化可能是促使成纤维细胞表型转化的关键因素。
参考来源 - 博莱霉素致肺纤维化小鼠肺组织中P65、α·2,447,543篇论文数据，部分数据来源于NoteExpress
To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction(UUO)rats.
目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。
Estrogen can prevent the development of interstitial fibrosis, the mechanism may with it restrain the tubular epithelial cell phenotype transdifferentiation in UUO rats.
结论雌激素可能通过抑制UUO大鼠肾小管上皮细胞表型转化而发挥延缓肾间质纤维化的作用。
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