大致有以下三种CSC起源假说: 1、CSC源自正常成体干细胞(normal stem cells,NSC)发生突变,多种因素引起NSC正常的更新分化调控机制过度激活而转化为恶性的CSC。
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normal human embryonic stem cells 和正常人胚胎干细胞
Sipkins said it appears the cancer overproduces a normally expressed molecule called a stem cell factor, which entices normal stem cells into the cancer niche.
斯普金思说,看来癌细胞大量产生一种以正常方式传送的分子,名为干细胞因子,这种分子会引诱正常干细胞到癌细胞的处所。
These cells are termed cancer stem cells because, like normal stem cells, they possess the ability to self-renew and make differentiated progeny.
它们之所以像正常干细胞一样被冠以此名,是因为它们具有自我更新和形成分化子代的能力。
These cancer stem cells share many characteristics with normal stem cells, including self-renewal and differentiation.
这些癌症干细胞与正常的干细胞有许多共同的特点,包括自我更新和分化。
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