The chemical modification of sugar moiety in nucleoside or nucleotide is always an important way to discover new lead compounds with anti-viral, anti-tumor and other biological activities.

对核苷类化合物糖环部分的化学改造一直是发现新的具有抗病毒、抗肿瘤或其他生物活性的核苷类先导化合物的重要途径之一。

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In this paper, according to the principles of new drug design, On the basis of former research the 10 compounds guided by the lead compound PHR0007 were synthesized.

本文在前人研究的基础上，以PHR0007为先导化合物，按着新药设计原理合成了10个未见文献报道的化合物。

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The invention can provide lead compounds for the development of new anti-cancer drugs and is expected to become the drugs for cancer treatment.

本发明可为研制新的抗肿瘤药物提供先导化合物，可望成为治疗癌症的药物。

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Ultimately such compounds could lead to promising new painkillers, but to reach that stage GSK's labs first have to test hundreds of thousands of different compounds with the vanilloid receptor, hunting for the ones that bind.

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