The association should be coherent; that is, plausible and explicable biologically according to known facts in the natural history and biology of the disease.

相关性应是合理的；也就是说，根据疾病的自然史和生物学上的已知事实，可以从生物学角度来解释相关性。

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With such a variety of factors, it is no wonder that scientists don't fully understand the natural history of the disease.

纵观以上各种不同的因素，无怪科学家们还未完全弄清致病的天然历史。

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First, from a patient's point of view, there are several useful findings about the natural history of rotator cuff disease and the clinical course that asymptomatic rotator cuff tears follow.

第一，从患者的角度来说，关于肩袖疾病自然病程和临床结局的这些发现，对于患有肩袖撕裂的患者非常有用。

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"Surgery produced a one-time benefit but did not modify the subsequent natural history of the disease, " the doctors said.

BBC: Doctors back 'controversial' operation

Instead, researchers use these so-called natural-history studies to gain a better understanding of how the disease progresses without treatment and to track different symptoms.

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If a therapy eventually is developed, and a clinical trial begins, a natural-history study can be used to help evaluate whether it is working to slow or stop the disease.

WSJ: Families Push for New Ways to Research Rare Diseases