Geneticists and the general science community were first out of the block with their criticism, pointing out more than a dozen problems with the study.

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On a conference call, Glaxo executives argued that a more nuanced look at the study did not reveal heart problems.

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Study leader Dr Jeffrey Johnson said more research was needed to see if depression problems in teenagers were an early phase of major depressive disorder or if minor depression earlier in life contributed to the development of more serious problems later on.

BBC: Depressed teens 'face adult risk'