The most significant neuropathological change is a preferential loss of medium spiny neurons in the neostriatum.

最显著的神经病理改变是新纹状体中度多刺的神经元的优先丢失。

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It will be an enormous challenge for African countries to develop strategies that will enable them to mitigate the effects of climate change in the short, medium and long terms.

这将是非洲国家面临的一个巨大挑战，他们需要制定战略以便能够减轻气候变化带来的短期、中期和长期影响。

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Change is least likely in the physical medium of books.

书的物理介质不太可能发生变化。

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This will change dramatically in the case of brand immersive apps, as the medium will be an actual extension of the brand itself, becoming a vehicle to develop complementary revenue beyond the product sale.

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Such a recommendation implies a significant cut in current levels of spending, though it is suggested the change should be implemented in the medium term.

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"One advantage it has over other services is that it can change quickly if hashtags become a polluted medium and it might keep one step ahead of the spammers, " he said.

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