Because of the large deformation of the soft base structure, the pavement would have fatigue failure under heavy load to make the road losing its function.

柔性基层结构由于基层结构变形大，在重载交通条件下，路面面层短期内在重复荷载作用下易产生疲劳破坏，导致路面结构层的功能丧失。

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In this case, the worm Caenorhabditis elegans (C. elegans) was found by scientists at Rutgers University in New Jersey, US, to losing its muscle mass and strength as it aged, without any accompanying loss in nervous system function.

BBC: Waistline secrets revealed by worms