The trouble with this solution is that it no longer is practical on a large scale.

这种方法的问题在于无法大规模地进行实践。

youdao

The result is that it no longer makes sense to name queue managers in a business context; for example, by application name.

其结果在于，在业务上下文中命名队列管理器不再有意义；例如，按应用程序名称命名队列管理器。

youdao

The pit is being shut down because it no longer has enough coal that can be mined economically.

那个煤矿要关闭了，因为储量不足，难以经济开采。

《柯林斯英汉双解大词典》

Even after being processed at the city's water treatment plants the water takes another journey through leaky pipes that ensure it is no longer drinkable once it reaches people's homes.

VOA: standard.2010.08.04

Now you can actually go, now that I realize that Libya is now open; it's no longer a closed territory.

现在你确实可以去那个地方,据我所知,现在利比亚已经对外开放,不再是一个封闭国家

耶鲁公开课 - 古希腊历史简介课程节选

And details aside,death is a matter of the body breaking, so that it's no longer able to engage in P-functioning.

除开其他细节，死亡只是肉体的破坏，以至于不能再实施人格功能。

耶鲁公开课 - 死亡课程节选

What is interesting is that it no longer reflects the simplistic divide between doubters and believers.

BBC: Europe's summer of argument

The problem with publishing some stories that are two thousand times as important as others is that it no longer makes sense to display them in reverse chronological order.

NEWYORKER: Search and Destroy

What is significant is that it is no longer just the unions on the streets.

BBC: Spain's euro woes: Crisis deepens