Our research mainly study the two-way mediated mechanism of APS that promote haematopoiesis、Inhibite leukemia cell、proliferate and induce cell differentiation. This finding will provide theoretical and experimental evidence for exploiting and utilizing Angelica.
本课题旨在从信号传导角度探讨APS即能促进正常造血又能抑制白血病细胞增殖并诱导分化的双向调控机制,并为进一步开发和利用当归多糖提供实验依据。
参考来源 - 当归多糖调控造血细胞和K562白血病细胞增殖分化信号传导机制的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
Conclusions SPB can apparently inhibit the proliferation of C6 cells and can induce cell differentiation and even apoptosis of C6 cells.
结论苯丁酸钠可明显抑制C6细胞增殖，诱导细胞分化，甚至诱发细胞凋亡。
Agents that induce cell differentiation have been widely used in tumor research and achieved progress in the prevention and treatment of tumor. among them, retinoid drug shows confirmative effect.
分化诱导剂被广泛应用于肿瘤的研究，在肿瘤的预防和治疗方面取得一定的进展，其中以维甲酸类药物效果肯定。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
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