Objective:To establish a rapid and simple HPLC method for the determination of adefovir dipivoxil and its metabolites in the rat plasma in vitro.
目的：建立一种快速、简单的测定大鼠血浆中阿德福韦酯水解产物阿德福韦单特戊酸甲基酯和阿德福韦的离子对反相高效液相色谱方法。
Conclusions the determination method is simple and swift, and can be applied in the determination of in vitro release rate of metformin hydrochloride sustained-release tablets.
结论本释放度方法简单，快速，可用于盐酸二甲双胍缓释片体外释放度测定。
Methods: in vitro cell culture, MTT titration, NBT reduction and phagocytosis determination were employed to study the effects of JLC on HL-60 cells.
方法：利用体外细胞培养、MTT、NBT染色及吞噬功能测定等方法，观察在不同浓度金龙胶囊作用下人早幼粒白血病细胞系(HL - 60)的细胞形态和功能的变化。
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