Also provided are humanized antibodies and fragments thereof that bind to the TF.

本发明也提供结合至该TF的人源化抗体及其片段。

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Because this method was to simulate the process of antibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.

该方法体外模拟了抗体亲和力成熟的过程，使得到的抗体不但可以完全的人源化，而且可以具有较高的亲和力。

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The invention further relates to humanized and human PAM4 antibodies, and the use of such antibodies in diagnosis and therapy.

本发明还涉及人源化pam4抗体和人pam4抗体以及所述抗体在诊断和治疗中的用途。

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