文章详细信息 关键词: 热熔挤出技术;;差示扫描量热;;溶出度;;固体分散体 [gap=911]Keywords: hot-melt extrusion;DSC;dissolution;solid dispersion
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Objective To prepare indomethacin immediate release capsules by means of hot-melt extrusion (HME) using indomethacin as the model drug.
目的以热熔挤出技术制备吲哚美辛速释胶囊。
The equipments, processes, excipients in common use and influence factors as well as applications in pharmaceutical fields of the hot-melt extrusion technology are reviewed.
综述了熔融挤压法的设备、特点、工艺过程、常用辅料及影响因素,并对其在工业药剂学上的应用进行了概述。
Objective: To assess if the hot melt extrusion (HME) technique enhances the dissolution of hydrophobic drugs.
目的:研究热熔挤出技术是否提高难溶性药物溶出度。
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