目前大剂量氨甲喋呤（high dosemethotrexate，HD MTX) 成为儿童髓外白血病防治的重要手段［1］，但MTX 具有潜在的细胞 毒性，且剂量越大，出现不良反应的...
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Objective To study the clinic features and the mechanism of skin damage induced by high-dose methotrexate (HD-MTX).
目的了解大剂量氨甲蝶呤(HD - MTX)化疗引起皮肤损伤的临床特征，并探讨其发生机制。
Objective To discuss the practicability of high-dose methotrexate (HD-MTX) in treatment of acute lymphoblastic leukemia (ALL) in children in basic-level hospitals.
目的探讨大剂量甲氨蝶呤(HD - MTX)治疗急性淋巴细胞白血病(all)在基层医院的可行性。
Method Children treated with HD-MTX were enrolled in a retrospective study in which the incidence and presentations of skin damage were concluded.
方法总结儿童HD - MT X化疗致皮肤损伤的临床表现，并分析其发病机制。
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