"Our study would strongly suggest that it is not beneficial to do it as front-line treatment but to reserve it as second-line or salvage therapy, " said study leader Dr. MarkGilbert of the University of Texas MD Anderson Cancer Center in Houston.
Though neither is a first time nominee--Smith nabbed a nod for his title role in Ali and DiCaprio snagged two for What's Eating Gilbert Grape and The Aviator--a win would mark the first time either took home a statuette.