Amyloid plaques form when a molecule called amyloid precursor protein (APP) is chopped up by two enzymes known as beta-secretase and gamma-secretase.

当一种叫淀粉样前体蛋白（APP）的分子被两种酶——分别叫作贝塔-分泌酶和伽玛-分泌酶——切断时就形成了淀粉样斑块。

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Eberhart and colleagues studied glioblastoma cell lines to investigate the effects of a gamma-secretase inhibitor, a medication that blocks the Notch receptor, on tumor growth.

埃伯哈特和他的同事们研究了恶性胶质瘤的细胞系以发现γ-内分泌酶抑制剂的影响，这种药物可阻断促使肿瘤增长的Notch受体途径。

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By this point Eli Lilly had resurrected its gamma-secretase program.

FORBES: Executive Health

Lilly is testing its gamma-secretase inhibitor on 1, 500 patients.

FORBES: Magazine Article

But if the toxic effects were caused directly by the intended effect of the drug (blocking gamma secretase), that would raise serious questions as to whether it is safe to continue with other trials of gamma secretase drugs now ongoing at other drug companies including Bristol-Myers Squibb.

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