First of all, let me ask you something.

首先，让我问你一件事。

《牛津词典》

First of all we must identify the problem areas.

首先我们必须找出问题所在。

《牛津词典》

First of all, there are not many of them, and secondly, they have little money and, thirdly, they're hungry.

首先，他们人数不多；第二，他们没什么钱；第三，他们在挨饿。

《柯林斯英汉双解大词典》

Well,first of all, the twenty-second and twenty-fourth presidents of the United States were the same person.

VOA: special.2009.07.24

It's first of all a depiction of an underworld, and so it provides Milton with an important Christian representation of a hell.

它首先是对地狱的一个描述，它为弥尔顿提供了,一个重要的基督教式的地狱的描绘。

耶鲁公开课 - 弥尔顿课程节选

I would first of all, congratulate you for taking the first step of starting to learn that process.

我会首先祝贺你踏出了学习语言的第一步，

学第二外语的时候 - SpeakingMax英语口语达人

First of all, if MRSA is caught early, it's completely curable with one of the antibiotics.

NPR: Tracking a New Strain of Drug-Resistant Staph

First of all, the mayor of Cleveland, Frank Johnson -- Frank Jackson is here.

WHITEHOUSE: Winning the Future Forum on Small Business: Closing Session | The White House

First of all, they found that the spectra for each planet was vastly different.

FORBES: Astronomers Conduct 'Reconnaissance' Of Another Solar System