• 排泄 - 引用次数：2

  Results: 11C-HupA was of the characteristic that quickly discharge from the blood,which half time was 14.608±1.773min,clearance rate was 0.12±0.009ml/min/kg, metabolism through the liver,kidney was the main eccrisis organ,which was 3.562±0.360%ID/g at 15 min and decreasing graduately,it was 2.547±0.337ID/g in liver at 15 min,Until 60 min the discharging of 11C-HupA was keeping in a relative higher level. Pharmacokinetics of 11C-HupA in the rats corresponded to one-compartment model.

  结果;11C-HupA进入大鼠体内具有血液清除快的特点,半衰期为14.608±1.773min,药物自体内总清除率为0.12±0.009ml/min/kg,经肝胆系统代谢,肾组织是11C-HupA的主要排泄器官,在15min达到高峰,为3.562±0.360%ID/g,之后呈逐渐下降的趋势,肝脏在15min为2.547±0.337ID/g,60min之前放射性分布维持在较高的水平。

  参考来源 - 正电子发射断层（PET）基础与临床研究：~（11）C

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