骨靶向性柔性纳米脂质体 线下面积（area under curve,AUC）为N-UL的1.83倍,1.76倍和3.81倍,总靶向效率（drug targeting efficiency,DTE）提高了277.94%,203.12%和653.02%。结论：P-UL,12-UL,E-UL3种柔性纳
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Objective to modulate the molecular conformation of the hepatocyte targeting drug to increase exogenous gene expression efficiency in the targeted cell.
目的：用调整肝细胞靶向基因药物分子构形的方法，以期提高外源转入基因在目标细胞的表达效率。
Due to the specific bioactivity of peptides, peptide-based gene and drug delivery systems could achieve improved gene transfection efficiency, enhanced drug targeting property and reduced side-effect.
将具有特殊生理功能的多肽作为基因或药物载体、或用于药物修饰等，可以提高基因转染效率，增强药物的靶向治疗效果，降低药物的毒副作用。
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