...依 赖性钙通道，抑制Ca 2 + 内流的药物，属于强效力、水溶性的第二代二氢吡啶类钙拮抗剂（dihydropyridine calcium antagonists，DHPs）。尼卡地平结构中二氢吡啶环的4 位为不对称碳原子，故具有两个对映体。
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OBJECTIVE:To summarize the aspect of clinical usage and progress on the dihydropyridine calcium antagonists, and evaluate its clinical efficacy and safety.
目的：阐述二氢吡啶类钙通道阻滞剂的进展和临床应用的历程，评价其疗效与安全性。
Edema associated with dihydropyridine calcium antagonists is a localized phenomenon involving varying differences in arteriole and venous dilation and does not appear to be related to heart failure.
二氢吡啶类钙拮抗剂引起的水肿为局部症状，包括动脉和静脉扩张的不同差异，似与心力衰竭无关。
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