Despite the obvious setbacks, it is not all doom and gloom for the England team.

尽管明显受挫，但对英格兰队来说绝非胜利无望。

《牛津词典》

Despite all the setbacks that first year, we made it happen, and I learned some awfully valuable lessons.

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Despite all the setbacks, diplomats and aid administrators try to remain hopeful.

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The setbacks did not make difference however as Gloucester dominated all aspects of the game, despite Bristol's best efforts.

BBC: SPORT | Rugby Union | English | Bristol 9-41 Gloucester