Objective: To investigate the expression of BRCA1 protein in sporadic ovarian cancer and its significance.

目的：探讨散发性卵巢癌组织中BR CA1蛋白的表达及其意义。

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Methods The expression of ERCC1, RRM1 and BRCA1 protein in 122 cases of advanced NSCLC was detected by immunohistochemical methods.

方法应用免疫组织化学方法对122例晚期NSCLC组织进行ERCC1、RRM1及BRCA1蛋白表达检测。

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In normal cells, the BRCA1 protein keeps these regions silent by tagging histones, or DNA packaging proteins, with a molecule called ubiquitin.

在正常细胞中，通过组蛋白标记或DNA包装蛋白，在泛素分子的作用下，BRCA1蛋白使这些区域保持沉默。

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If the test proves negative, it suggests that the protein is not being produced properly, which is a clue that the BRCA1 gene may not be normal.

BBC: DNA spiral