This plan need not be expensive, but it faces one big difficulty.

这项计划花费不大，但却面临一个很大的难题。

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This gives the exploitation of combustible ice is a big difficulty.

这给可燃冰的开采带来了很大的困难。

youdao

My height is a big difficulty to match with other actresses in Taipei.

我的身高是最大的困扰因为要搭配台北的女演员。

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Language is another big difficulty.

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But, she notes, he might have sympathised with her over one big problem: the surprising difficulty of changing medical routine.

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But his difficulty in giving that big speech on Europe in about a week's time is what if he's wrong on any one of those ifs?

BBC: David Cameron says there will be EU referendum if...