Opening a book or raising hands, some very easy actions for common people, however, are big challenges for Xu.

翻开一本书或举手，这些对于普通人来说很简单的动作，但对徐来说却是些巨大的挑战。

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But there are some big challenges.

但是有一些巨大的挑战。

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Big challenges demand strong leaders.

强大的挑战总需要强势的领导者。

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we've got seven or eight big problems." And as he took on those challenges, a presidential style emerged.

VOA: standard.2010.01.16

In fact, we'll talk about that concept throughout the course because one of the big challenges of making these sort of new biological therapies work in people to treat diseases is getting the right molecules into the right cells, at the right period of time.

实际上,我们会讲到一个,贯穿这门课程的概念,因为为了治疗疾病,而采用的新型生物学疗法,所面临的一个大问题就是,如何将正确的分子在适当的时候,转进正确的细胞当中

耶鲁公开课 - 生物医学工程探索课程节选

The nation faces two big challenges: In the short term, the economy is still extremely fragile.

FORBES: The Debt Deal is a Bad Deal

Lifestyle change, including diet and exercise, is the mainstay remedy, although it poses big challenges.

WSJ: Heart-Attack Risk Starts Younger

There are two big challenges in looking at your contributions in terms of dollars and cents.

FORBES: Annual Performance Review: Time Suck or Amazing Opportunity