It was never delivered, despite his best efforts to do so in person, and now it never will be.

尽管他竭尽全力想亲自交给收信人，但这封信一直没寄出去，以后也永远都寄不了了。

youdao

It beats us all the time - not just with eating, but with anything we try to do and end up quitting, caving in, doing it despite our best efforts.

它在所有的事情上都打败了我们——不仅仅是关于吃东西，还有关于任何我们尝试做但最终以放弃告终的事情上，并且屈服，尽管我们做出了最大的努力还是失败了。

youdao

At the Office of Commercial Space Transportation, we'll certainly do our best to keep up, and to help those of you in industry to be both safe and successful in your efforts. It won't be easy.

我们商业太空运输办公室的工作人员将全力以赴，协助业内人士安全和成功地开展工作。

youdao

Another doctor contacted the MPS for advice about a patient who had been diagnosed HIV positive, and who was adamant in his refusal to inform his wife, despite the doctor's best efforts to persuade him to do so.

BBC: When do you break a patient's confidence?

The Justice Department is confident its settlement administrator "will be successful in locating the vast majority of the victims and is committed to ensuring that best efforts are made to do so, " spokeswoman Xochitl Hinojosa said.

WSJ: Victims Sought in Countrywide Case

Having already lived through a major challenge as a young teenager, she knew the best thing to do was to avoid playing the victim, and to instead focus her efforts on what she could do today and tomorrow.

FORBES: How a Subtle Difference in Attitude Transformed a Small Store into a Global Brand