Under electronic microscope the changes of cerebral ultrastructure and BBB permeability were observed.
硝酸镧心脏灌注法固定鼠脑，透射电镜下观察脑超微结构与BBB改变。
There was no significant changes in BBB permeability among hemin, ZnPP and saline groups in noninfarcted side(P>0.05).
血红素氧合酶诱导剂、抑制剂对非梗塞侧的血脑屏障通透性没有影响（P＞0.05）。
Conclusion: the BBB permeability may increase after acute severe scald, which can be significantly restricted by pretreatment with L-NAME at the early stage.
结论：严重烫伤可导致脑bbb通透性增高，早期应用L - NAME能明显减轻烫伤对脑bbb的损伤。
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