另一方面,Hh通路活性的升高与多种肿瘤包括在北美确诊的癌症中占第一位的基底细胞癌(basal cell carcinomas,BCCs)都相关。Hh信号通常被肿瘤抑制物Patched(Ptch1)所限制。
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multiple basal cell carcinomas 多发性基底细胞癌
basal cell carcinomas bcc 基底细胞癌
basal cell carcinomas of eyelid 眼睑基底细胞癌
Basal cell carcinomas can appear in some pretty strange places, including the eyelid, where it often causes a sore and the loss of eyelashes.
基底细胞癌可以出现在一些非常奇怪的地方，包括眼睑，在那里它经常引起疼痛和睫毛脱落的现象。
Basal cell carcinomas are the most common form of skin cancer overall, and also the most common epithelial tumor of the eyelid.
总的来说，基底细胞癌是最常见的皮肤癌类型，其也是最常见的眼睑上皮肿瘤。
A total of 472 basal cell carcinomas and 309 squamous cell carcinomas were diagnosed during a median follow-up of 3.4 years.
在接下去的中位数为3.4年的随访中，总共有472人被诊断为基底细胞癌，309人被诊断为鳞状上皮细胞癌。
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