The mutations, including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21, cluster around ATP-binding pocket of TK domain.

这些突变均发生在酪氨酸激酶域的ATP结合域附近，突变为19号外显子上的缺失突变，或18和21号外显子上的替代突变。

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The conserved surface patch and the deep pocket are responsible for binding to PP2A and ATP, respectively.

这种保守的表面补丁和深口袋负责分别与PP2A和ATP结合。

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