If you don't anticipate what may happen, you'll find yourself at a loss when sth. crops up.

你如果没有思想准备，事到临头就会抓瞎。

《新英汉大辞典》

Should you find yourself at a loss and pondering what is life all about, asking what is my purpose?

如果你发现自己不知所措，并在思考：生活到底是什么，我的目标是什么？

youdao

You are my love to be at a loss what to do, people rely on unsuspectingly, how can you go.

你是我不知所措的爱，懵懵懂懂想要依赖着的人，怎么可以走掉。

youdao

Rather, the US government will sell it, at a discount (what you and I might call a loss), to ethanol producers.

FORBES: David Ricardo's Sugar Rush

"You want to be playing at your best going into the tournament and you can't afford a loss at this point in the season where you're questioning your lineups and what your identity is, " Plumlee said.

NPR: No. 3 Duke Hammers North Carolina 69-53