In addition to his many papers exploring the basic science of the renin-angiotensin system, Matsubara was the chief investigator of the KYOTO HEART Study, a randomized, open-labeled trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.
Add to the mix medium-run uncertainty (i.e. several years down the road) about the effect of the recent health care legislation and financial regulatory reform.