The change of boss is likely to lead to a period of turmoil at Areva at a time when it is already facing a difficult future as utilities may delay or cancel orders for reactors following Fukushima.

由于福岛核事故，公共部门可能会搁置或者取消反应炉的定单，在阿海珐集团已经面临一个艰难前景之际更换总裁可能会导致其经受动荡时期。

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Over a period of time, you will gain more control of your emotions as you learn to breathe through difficult situations.

一段时间后，通过学习一些困难条件下的呼吸，你将能够更好地控制你自己的情绪。

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The time when I first met Nelson Mandela was a very difficult period of my life.

第一次见到纳尔逊·曼德拉的时候是在我一生中非常艰难的时期。

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Now,that has changed, for sure; but,the centralization of the French government and the domination of Paris over the life of the nation is very difficult to change, over a long period of time.

现在,情况已经发生了改变,但是法国政府的中央集权化,以及巴黎在国民生活中的支配地位,在相当时间段内,都很难得以改变

耶鲁公开课 - 1871年后的法国课程节选

The typical clinical trial model may not be best suited for generating evidence that a drug is safe and effective against diseases where patient enrollment can be difficult and diseases progress slowly and unevenly over a long period of time, according to Steven Grossman, who worked on the original Orphan Drug Act in 1983 and is now a policy and regulatory consultant.

FORBES: Orphan Drugs: 'Rare' Opportunities To Make Money

It took him almost eight weeks to recover, a period of time the athlete has described as "fairly difficult" as it marked the first season in four or five years in which he didn't record a personal best.

CNN: February 14, 2013 -- Updated 1700 GMT (0100 HKT)