Amyloid plaques form when a molecule called amyloid precursor protein (APP) is chopped up by two enzymes known as beta-secretase and gamma-secretase.

当一种叫淀粉样前体蛋白（APP）的分子被两种酶——分别叫作贝塔-分泌酶和伽玛-分泌酶——切断时就形成了淀粉样斑块。

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Eberhart and colleagues studied glioblastoma cell lines to investigate the effects of a gamma-secretase inhibitor, a medication that blocks the Notch receptor, on tumor growth.

埃伯哈特和他的同事们研究了恶性胶质瘤的细胞系以发现γ-内分泌酶抑制剂的影响，这种药物可阻断促使肿瘤增长的Notch受体途径。

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For the past decade there has been a lot of work on drugs called secretase inhibitors, which alter the activity of the enzymes that create amyloid beta-peptide 42.

在过去的10年里人们对被称为分泌酶抑制剂的药物进行了大量研究，这种药物可以改变酶类产生淀粉样贝塔-肽42的活动。

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Do you think there is a safety issue with other gamma secretase inhibitors going forward in testing, such as the one Bristol-Myers Squibb is testing?

FORBES: Renegade Researcher Says Alzheimer's Drugs From Bristol-Myers, Pfizer May Be Unsafe Or Ineffective

Researchers in Iceland identified a rare genetic mutation that slows the activity of an enzyme called beta secretase, which is required to produce amyloid-beta.

FORBES: Solving The Fatal Puzzle Of Alzheimer's Disease