...突变(T315/F317):直接妨碍伊马替尼与催化结构域结合;③催化结构域内突变(位点350-363):影响激酶活性;④活化环(A-loop)突变(位点381-402):阻碍激酶向非活化状态转化从而使伊马替尼失效。
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当配体与FLT3的细胞外结构域结合时,FLT3三聚体化,其激酶结构域的活化环(activation loop,A-loop)构象发生改变,酷氨酸残基磷酸化,通过与多种胞浆蛋白如RAS-GTP酶激活蛋白、磷脂酶C及Src家庭酷...
基于2个网页-相关网页
当配体与FLT3的细胞外结构域结合时,FLT3三聚体化,其激酶结构域的活化环(activation loop,A-loop)构象发生改变,酷氨酸残基磷酸化,通过与多种胞浆蛋白如RAS-GTP酶激活蛋白、磷脂酶C及Src家庭酷...
基于2个网页-相关网页
exit a loop 退出循环
Loop a Loop 绕一圈
range of a loop 循环域 ; 循环的区域
A loop 活化环 ; 结构域的活化环
In a loop 在循环中
plane of a loop 环平面
draw through a loop 从绒线处拉掉针数
Each week,the show took them - and viewers - on an emotional and mind-bending roller coaster ride, through a dizzying loop of supernatural forces, armed conspirators and,of course,romance."
VOA: standard.2010.05.25
Once each time. Right? I only do one swap potentially, it-- though not one potentially, each time at the end of the loop I do a swap.
每次循环做一次,对么?我其实,就可能做了一次交换,也许并不是可能,每次循环的结束我都得做一次交换。
And there is a self-enforcing loop between the two, where helping others helps ourselves; and helping ourselves, in turn, helps others.
两者间有自我实施的循环,帮助他人就是帮助自己;,帮助自己继而帮助他人。
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