探讨达沙替尼对小鼠黑色素瘤b 16 F 10细胞株体外增殖、迁移和凋亡的影响。
To determine the effect of dasatinib on the proliferation, migration and apoptosis of murine melanoma cell line B16F10.
方法：将B16细胞株黑色素瘤对数生长期细胞接种于ICR小鼠足垫、皮下、腹腔和尾静脉等部位，建立移植瘤模型和肺部转移瘤模型。
Methods: Inoculating B16 Melanoma cells in ICR mice's feet, back, abdomen and caudal vein, to establish transplanted and metastatic melanoma models.
目的观察空间诱变小鼠黑色素瘤b 16细胞株的成瘤性，寻找免疫原性发生变异的细胞株。
Objective To explore the oncogenesis of the melanoma B16 cell clones mutagenized by space environment, and find the B16 cell clones with remarkably mutated immunogenicity.
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