骨形态发生蛋白质(bone morphogenetic protein,BMP),指从脊椎动物骨骼基质中分离提纯的蛋白质。具有内肽酶(含锌离子)活性、表皮生长因子模体,同源二聚体之间以二硫键相连,属于转化生长因子-β家族,能诱导骨与软骨形成。
骨形态发生蛋白(BMP)是一类具有高效成骨活性的蛋白质,因其能够异位诱导间充质细胞分化为软骨和骨细胞而形成新骨,在临床骨缺损修复中具有良好的应用前景。
Bone morphogenetic protein (BMP) has good potential in treatment for bone defects as it can induce mesenchymal cells to differentiate into cartilage cells and bone cells so to form new bone.
尤其是,新的发现提示该蛋白质复合物使响应来自倍受研究的骨形态发生蛋白信号途径(BMP signaling pathway)的有利于突触生长的信号的受体解除任务。
In particular, the new findings suggest that the protein complex decommissions receptors that respond to pro-growth signals coming from the well-studied BMP signaling pathway.
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