...的影响 - 淘金者论文 关键词】 青蒿素类；白血病；U937细胞；细胞增殖；细胞凋亡；细胞分化 [gap=1225]Keywords】 artemisinins; leukemia; U937 cells; cell proliferation; apoptosis; cell differentiation ..
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Artemisinins exert their antimalarial activity by iron-mediated cleavage. Recently, artemisinins exert their anticancer activity by blocking cell cycle, inducing apoptosis, inhibition of angiogenesis, accommodating the expressing of tumor related genes and damaging mitochondria.
近年来研究发现,青蒿素类药物还具有更广泛的药理作用,它可以通过阻滞细胞周期、诱导细胞凋亡、抗血管生成、调节肿瘤相关基因的表达以及损伤细胞线粒体等机制从而发挥抗肿瘤作用,其抗肿瘤作用日愈受到人们的重视。
参考来源 - 青蒿素类药物抗肿瘤作用机制的研究进展·2,447,543篇论文数据，部分数据来源于NoteExpress
问：世界卫生组织在早期开发青蒿素类复方药上发挥了何种作用？
Q: What role did the World Health Organization (WHO) play in the early development of ACT?
问：为何您在青蒿素耐药性并未引起关注的时候就研究青蒿素类复方药呢？
Q: Why did you research ACT for malaria at a time when there were no concerns about resistance to artemisinin?
另外，专家称，如果市场上只有青蒿素类的药品，一段时间以后最终还是会导致抗药性的出现。
What's more, public health experts say that the artemisinin-only pills on the market will inevitably engender drug resistance over time.
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