这一次的研究太零散，难以发挥重大的作用。

The research is too unfocused to have any significant impact.

《牛津词典》

但是，它们肯定起到了重大的作用。

But they certainly play a significant role.

youdao

这个看起来无意义的操作实际上有重大的作用。

This seemingly pointless operation actually has a significant effect.

youdao

Having been affected personally so much by music and how music has shaped my life i am driven to deeply explore with that impact with other people.

个人来说，音乐对我的人生,产生了重大的影响,我决定对它为其他人带来的作用,进行深入研究。

普林斯顿公开课 - 领导能力简介课程节选

And indeed Judah, the one who had figured so prominently in the sale of Joseph, that had crushed his father, Judah steps forward and offers himself instead of Benjamin: he says: It would kill my father now to lose Benjamin, the last son of his beloved wife, Rachel.

但确实是犹太，他在卖掉约瑟夫时作用重大，他击溃了他的亲身父亲，他向前一步，提出用自己交换本杰明：,他说：，现在失去了本杰明，我父亲就会死去，他是父亲爱妻Rachel的最后一个儿子。

耶鲁公开课 - 旧约导论课程节选