major disagreement ; significant disagreement ; significant divergence ; major divergence
... non-profit educational organization 非营利教育机构 profound differences 重大分歧 project one's rule 突出自己，表现自己 ...
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意见上有不可掩盖的重大分歧。
There are important differences of opinion which cannot be disguised.
youdao
这是很重要的是耐心和避免重大分歧。
It is important to be patient and avoid major disagreements.
麦凯恩正面临着与其他共和党人的重大分歧。
McCain faces a deep divide among Republicans.
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