当产物积累超出最佳数量时，它将与酶的一个氨酰基位点(变构位点)结合改变其形状，使其不能长时间与底物发生作用。
When the product accumulates beyond an optimal amount it binds to a site (ALLOSTERIC site) on the enzyme, changing the shape so that it can no longer react with its substrate.
胶原酶是一种特异降解胶原螺旋区或明胶，而不作用于其它蛋白质底物的酶类。
Collagenase is one kind of enzymes that can degrade native helical collagen fibrils or glutin but not degrade others proteins.
本文从酶、酶的作用底物和合成体系三个方面综述了酶法合成天冬甜精中的几个问题。
In this paper, several problems on the synthesis of Aspartame using the enzymatic methods were summarized, which involved the enzymes, substrates and synthesis systems.
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