中药资源丰富，作用靶点多，可针对多药耐药机制复杂的特点，现有研究亦提示开发中药肿瘤多药耐药逆转剂有较好的前景。

And many researchers pay attention to natural drugs. Traditional Chinese medicine has plentiful resource and multitarget, and it can aim directly to the complicated mechanisms of MDR.

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目的研究川芎嗪脂质体在体外对肿瘤细胞的细胞毒作用和对多药耐药的逆转作用，并研究脂质体剂型对上述作用的影响。

Objective: to study the cytotoxic effect of ligustrazine liposomes on tumor cell in vitro and the reversing effect on the MDR, and explore the influence of dosage form on the above effects.

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蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡，逆转多药耐药。

Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.

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